Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein

WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms tumor. Among its known functions, WTX interacts with the β-transducin repeat containing family of ubiquitin ligase adaptors and promotes the ubiquitination and degradation of the transcription factor β-catenin,...

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Detalles Bibliográficos
Autores principales: Camp, Nathan D., James, Richard G., Dawson, David W., Yan, Feng, Davison, James M., Houck, Scott A., Tang, Xiaobo, Zheng, Ning, Major, Michael B., Moon, Randall T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307315/
https://www.ncbi.nlm.nih.gov/pubmed/22215675
http://dx.doi.org/10.1074/jbc.M111.316471

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307315/
https://www.ncbi.nlm.nih.gov/pubmed/22215675
http://dx.doi.org/10.1074/jbc.M111.316471

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