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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington’s disease

Pathognomonic accumulation of ubiquitin (Ub) conjugates in human neurodegenerative diseases, such as Huntington’s disease, suggests that highly aggregated proteins interfere with 26S proteasome activity. In this paper, we examine possible mechanisms by which an N-terminal fragment of mutant huntingt...

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Detalles Bibliográficos
Autores principales: Hipp, Mark S., Patel, Chetan N., Bersuker, Kirill, Riley, Brigit E., Kaiser, Stephen E., Shaler, Thomas A., Brandeis, Michael, Kopito, Ron R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307690/
https://www.ncbi.nlm.nih.gov/pubmed/22371559
http://dx.doi.org/10.1083/jcb.201110093