Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function

BACKGROUND: One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial outer membrane during apoptosis. While Bax is mostly cytosolic and translocates to mitochondria following an apoptotic stimulus, Bak is constitutively integrated within the outer membrane. M...

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Detalles Bibliográficos
Autores principales: Ferrer, Pedro Eitz, Frederick, Paul, Gulbis, Jacqueline M., Dewson, Grant, Kluck, Ruth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307716/
https://www.ncbi.nlm.nih.gov/pubmed/22442658
http://dx.doi.org/10.1371/journal.pone.0031510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307716/
https://www.ncbi.nlm.nih.gov/pubmed/22442658
http://dx.doi.org/10.1371/journal.pone.0031510

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