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Translocation of a Bak C-Terminus Mutant from Cytosol to Mitochondria to Mediate Cytochrome c Release: Implications for Bak and Bax Apoptotic Function
BACKGROUND: One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial outer membrane during apoptosis. While Bax is mostly cytosolic and translocates to mitochondria following an apoptotic stimulus, Bak is constitutively integrated within the outer membrane. M...
Autores principales: | Ferrer, Pedro Eitz, Frederick, Paul, Gulbis, Jacqueline M., Dewson, Grant, Kluck, Ruth M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307716/ https://www.ncbi.nlm.nih.gov/pubmed/22442658 http://dx.doi.org/10.1371/journal.pone.0031510 |
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