Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux

Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis that the protective effect of α-crystallin is mediated by changes in cellular glutathione (GSH) and elucidated the mechanism of GSH efflux....

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Detalles Bibliográficos
Autores principales: Sreekumar, Parameswaran G., Spee, Christine, Ryan, Stephen J., Cole, Susan P. C., Kannan, Ram, Hinton, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307734/
https://www.ncbi.nlm.nih.gov/pubmed/22442691
http://dx.doi.org/10.1371/journal.pone.0033420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307734/
https://www.ncbi.nlm.nih.gov/pubmed/22442691
http://dx.doi.org/10.1371/journal.pone.0033420

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