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Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux
Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis that the protective effect of α-crystallin is mediated by changes in cellular glutathione (GSH) and elucidated the mechanism of GSH efflux....
Autores principales: | Sreekumar, Parameswaran G., Spee, Christine, Ryan, Stephen J., Cole, Susan P. C., Kannan, Ram, Hinton, David R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307734/ https://www.ncbi.nlm.nih.gov/pubmed/22442691 http://dx.doi.org/10.1371/journal.pone.0033420 |
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