Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

BACKGROUND: Recent studies suggest that betaKlotho (KLB) and endocrine FGF19 and FGF21 redirect FGFR signaling to regulation of metabolic homeostasis and suppression of obesity and diabetes. However, the identity of the predominant metabolic tissue in which a major FGFR-KLB resides that critically m...

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Detalles Bibliográficos
Autores principales: Yang, Chaofeng, Jin, Chengliu, Li, Xiaokun, Wang, Fen, McKeehan, Wallace L., Luo, Yongde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307775/
https://www.ncbi.nlm.nih.gov/pubmed/22442730
http://dx.doi.org/10.1371/journal.pone.0033870

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307775/
https://www.ncbi.nlm.nih.gov/pubmed/22442730
http://dx.doi.org/10.1371/journal.pone.0033870

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