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Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles

Protein kinases are attractive therapeutic targets, but their high sequence and structural conservation complicates the development of specific inhibitors. We recently discovered from a DNA-templated macrocycle library inhibitors with unusually high selectivity among Src-family kinases. Starting fro...

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Detalles Bibliográficos
Autores principales: Georghiou, George, Kleiner, Ralph E., Pulkoski-Gross, Michael, Liu, David R., Seeliger, Markus A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307835/
https://www.ncbi.nlm.nih.gov/pubmed/22344177
http://dx.doi.org/10.1038/nchembio.792