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Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles
Protein kinases are attractive therapeutic targets, but their high sequence and structural conservation complicates the development of specific inhibitors. We recently discovered from a DNA-templated macrocycle library inhibitors with unusually high selectivity among Src-family kinases. Starting fro...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307835/ https://www.ncbi.nlm.nih.gov/pubmed/22344177 http://dx.doi.org/10.1038/nchembio.792 |