INHIBITION OF MYCOLIC ACID TRANSPORT ACROSS THE MYCOBACTERIUM TUBERCULOSIS PLASMA MEMBRANE

New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis (M. tb) are urgently needed. We report on the identification of an adamantyl urea compound displaying potent bactericidal activity against M. tb and a unique mode of action, namely the abolition of the translocation...

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Detalles Bibliográficos
Autores principales: Grzegorzewicz, Anna E., Pham, Ha, Gundi, Vijay A. K. B., Scherman, Michael S., North, Elton J., Hess, Tamara, Jones, Victoria, Gruppo, Veronica, Born, Sarah E. M., Korduláková, Jana, Chavadi, Sivagami Sundaram, Morisseau, Christophe, Lenaerts, Anne J., Lee, Richard E., McNeil, Michael R., Jackson, Mary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307863/
https://www.ncbi.nlm.nih.gov/pubmed/22344175
http://dx.doi.org/10.1038/nchembio.794

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307863/
https://www.ncbi.nlm.nih.gov/pubmed/22344175
http://dx.doi.org/10.1038/nchembio.794

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