A fungal ketoreductase domain that displays substrate-dependent stereospecificity

Iterative highly-reducing polyketide synthases (HR-PKSs) from filamentous fungi are the most complex and enigmatic type of PKS discovered to date. Here we uncover an unusual level of programming by the hypothemycin HR-PKS, in which a single ketoreductase domain displays stereospecificity that is con...

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Detalles Bibliográficos
Autores principales: Zhou, Hui, Gao, Zhizeng, Qiao, Kangjian, Wang, Jingjing, Vederas, John C., Tang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307869/
https://www.ncbi.nlm.nih.gov/pubmed/22406519
http://dx.doi.org/10.1038/nchembio.912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307869/
https://www.ncbi.nlm.nih.gov/pubmed/22406519
http://dx.doi.org/10.1038/nchembio.912

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