An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination

The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the C-terminal IR-tail of the APC activator Cdc20 for APC binding. Here we show that...

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Detalles Bibliográficos
Autores principales: Zeng, Xing, King, Randall W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307893/
https://www.ncbi.nlm.nih.gov/pubmed/22366722
http://dx.doi.org/10.1038/nchembio.801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307893/
https://www.ncbi.nlm.nih.gov/pubmed/22366722
http://dx.doi.org/10.1038/nchembio.801

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