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An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination

The Anaphase-Promoting Complex/Cyclosome (APC) is a ubiquitin ligase required for exit from mitosis. We previously showed that Tosyl Arginine Methyl Ester (TAME) inhibits APC-dependent proteolysis by competing with the C-terminal IR-tail of the APC activator Cdc20 for APC binding. Here we show that...

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Detalles Bibliográficos
Autores principales:	Zeng, Xing, King, Randall W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3307893/ https://www.ncbi.nlm.nih.gov/pubmed/22366722 http://dx.doi.org/10.1038/nchembio.801

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