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Beyond amyloid: a diverse portfolio of novel drug discovery programs for Alzheimer's disease and related dementias

Although the molecular mechanisms underlying the pathogenesis of Alzheimer's disease and other related neurodegenerative diseases remain unclear, accumulation of misfolded proteins, neuroinflammation, mitochondrial dysfunction and perturbed calcium homeostasis have been identified as key events...

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Detalles Bibliográficos
Autores principales: Lane, Rachel F, Shineman, Diana W, Fillit, Howard M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308025/
https://www.ncbi.nlm.nih.gov/pubmed/22236739
http://dx.doi.org/10.1186/alzrt99