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A novel patch assembly domain in Num1 mediates dynein anchoring at the cortex during spindle positioning

During mitosis in budding yeast, cortically anchored dynein generates pulling forces on astral microtubules to position the mitotic spindle across the mother–bud neck. The attachment molecule Num1 is required for dynein anchoring at the cell membrane, but how Num1 assembles into stationary cortical...

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Detalles Bibliográficos
Autores principales: Tang, Xianying, Germain, Bryan St., Lee, Wei-Lih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308694/
https://www.ncbi.nlm.nih.gov/pubmed/22431751
http://dx.doi.org/10.1083/jcb.201112017