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Using Intramolecular Disulfide Bonds in Tau Protein to Deduce Structural Features of Aggregation-resistant Conformations

Because tau aggregation likely plays a role in a number of neurodegenerative diseases, understanding the processes that affect tau aggregation is of considerable importance. One factor that has been shown to influence the aggregation propensity is the oxidation state of the protein itself. Tau prote...

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Detalles Bibliográficos
Autores principales: Walker, Sophie, Ullman, Orly, Stultz, Collin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308815/
https://www.ncbi.nlm.nih.gov/pubmed/22291015
http://dx.doi.org/10.1074/jbc.M111.336107