Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

BACKGROUND: Angiopoietin-2 (Ang2), a ligand for endothelial TEK (Tie2) tyrosine kinase receptor, is induced in hypoxic endothelial cells of tumors, where it promotes tumor angiogenesis and growth. However, the effects of Ang2 on tumor lymphangiogenesis and metastasis are poorly characterized. METHOD...

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Detalles Bibliográficos
Autores principales: Holopainen, Tanja, Saharinen, Pipsa, D’Amico, Gabriela, Lampinen, Anita, Eklund, Lauri, Sormunen, Raija, Anisimov, Andrey, Zarkada, Georgia, Lohela, Marja, Heloterä, Hanna, Tammela, Tuomas, Benjamin, Laura E., Ylä-Herttuala, Seppo, Leow, Ching Ching, Koh, Gou Young, Alitalo, Kari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309130/
https://www.ncbi.nlm.nih.gov/pubmed/22343031
http://dx.doi.org/10.1093/jnci/djs009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309130/
https://www.ncbi.nlm.nih.gov/pubmed/22343031
http://dx.doi.org/10.1093/jnci/djs009

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