Cargando…

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

BACKGROUND: Angiopoietin-2 (Ang2), a ligand for endothelial TEK (Tie2) tyrosine kinase receptor, is induced in hypoxic endothelial cells of tumors, where it promotes tumor angiogenesis and growth. However, the effects of Ang2 on tumor lymphangiogenesis and metastasis are poorly characterized. METHOD...

Descripción completa

Detalles Bibliográficos
Autores principales:	Holopainen, Tanja, Saharinen, Pipsa, D’Amico, Gabriela, Lampinen, Anita, Eklund, Lauri, Sormunen, Raija, Anisimov, Andrey, Zarkada, Georgia, Lohela, Marja, Heloterä, Hanna, Tammela, Tuomas, Benjamin, Laura E., Ylä-Herttuala, Seppo, Leow, Ching Ching, Koh, Gou Young, Alitalo, Kari
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309130/ https://www.ncbi.nlm.nih.gov/pubmed/22343031 http://dx.doi.org/10.1093/jnci/djs009

Ejemplares similares

Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems
por: Eklund, Lauri, et al.
Publicado: (2016)

Endothelial destabilization by angiopoietin-2 via integrin β1 activation
por: Hakanpaa, Laura, et al.
Publicado: (2015)

Anti-angiogenic Targets: Angiopoietin and Angiopoietin Receptors
por: Kiss, Elina A., et al.
Publicado: (2019)

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma
por: Rautiola, Juhana, et al.
Publicado: (2016)

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions
por: Zheng, Wei, et al.
Publicado: (2014)

VEGF-C is required for intestinal lymphatic vessel maintenance and lipid absorption
por: Nurmi, Harri, et al.
Publicado: (2015)

Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2
por: Saharinen, Pipsa, et al.
Publicado: (2005)

Comparison of Automated and Traditional Western Blotting Methods
por: Sormunen, Aino, et al.
Publicado: (2023)

Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects
por: Saaristo, Anne, et al.
Publicado: (2002)

Angiopoietin-2 blocking antibodies reduce early atherosclerotic plaque development in mice
por: Theelen, Thomas L., et al.
Publicado: (2015)

Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting
por: Wirzenius, Maria, et al.
Publicado: (2007)

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer
por: Sallinen, Hanna, et al.
Publicado: (2014)

Fighting vessel dysmorphia to improve glioma chemotherapy
por: Lohela, Marja, et al.
Publicado: (2017)

The TIE Receptor Family
por: Saharinen, Pipsa, et al.
Publicado: (2015)

Improved endothelialization of small-diameter ePTFE vascular grafts through growth factor therapy
por: Hytönen, Jarkko P, et al.
Publicado: (2019)

Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance
por: Kapiainen, Emmi, et al.
Publicado: (2022)

Gene Therapy Used in Cancer Treatment
por: Wirth, Thomas, et al.
Publicado: (2014)

Therapeutic Potential of VEGF-B in Coronary Heart Disease and Heart Failure: Dream or Vision?
por: Mallick, Rahul, et al.
Publicado: (2022)

Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance T(RAFFn), T(1ρ) and T(2) relaxation times
por: Ylä-Herttuala, Elias, et al.
Publicado: (2023)

Zebrafish Tie-2 shares a redundant role with Tie-1 in heart development and regulates vessel integrity
por: Gjini, Evisa, et al.
Publicado: (2011)

Downregulation of VEGFR3 signaling alters cardiac lymphatic vessel organization and leads to a higher mortality after acute myocardial infarction
por: Vuorio, Taina, et al.
Publicado: (2018)

Targeting β1-integrin inhibits vascular leakage in endotoxemia
por: Hakanpaa, Laura, et al.
Publicado: (2018)

Promoting blood vessel growth in ischemic diseases: challenges in translating preclinical potential into clinical success
por: Dragneva, Galina, et al.
Publicado: (2013)

Dotted collar placed around carotid artery induces asymmetric neointimal lesion formation in rabbits without intravascular manipulations
por: Kivelä, Antti, et al.
Publicado: (2012)

Characterization of a new IN-I-PpoI fusion protein and a homology-arm containing transgene cassette that improve transgene expression persistence and 28S rRNA gene-targeted insertion of lentiviral vectors
por: Nousiainen, Alisa, et al.
Publicado: (2023)

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
por: Nilsson, Ingrid, et al.
Publicado: (2010)

The possible dual role of Ang-2 in the prognosis of pancreatic cancer
por: Roos-Mattila, Matilda, et al.
Publicado: (2023)

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart
por: Naumenko, Nikolay, et al.
Publicado: (2017)

A New Gene Therapy Approach for Cardiovascular Disease by Non-coding RNAs Acting in the Nucleus
por: Husso, Tiia, et al.
Publicado: (2014)

Nucleic Acid–Based Therapies for Atherosclerosis
por: Mäkinen, Petri, et al.
Publicado: (2020)

Novel RNAi-Based Therapies for Atherosclerosis
por: Ruotsalainen, Anna-Kaisa, et al.
Publicado: (2021)

The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
por: Anisimov, Andrey, et al.
Publicado: (2023)

Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression
por: Korhonen, Emilia A., et al.
Publicado: (2022)

Viral-Vector-Delivered Anti-Angiogenic Therapies to the Eye
por: Koponen, Sanna, et al.
Publicado: (2021)

Epigenetic Regulation of Vascular Smooth Muscle Cell Phenotype Switching in Atherosclerotic Artery Remodeling: A Mini-Review
por: Zurek, Michelle, et al.
Publicado: (2021)

Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes
por: Robciuc, Marius R., et al.
Publicado: (2012)

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice
por: Dijkstra, M. H., et al.
Publicado: (2014)

Differential Regulation of Vascular Endothelial Growth Factors by Promoter-targeted shRNAs
por: Laham-Karam, Nihay, et al.
Publicado: (2015)

Editorial: Vascularization for Regenerative Medicine
por: Banfi, Andrea, et al.
Publicado: (2018)

Experimental Evaluation of an Interferometric Light Microscopy Particle Counter for Titering and Characterization of Virus Preparations
por: Turkki, Vesa, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bgghugfc1b27rgd1cofcb2kinl