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How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure

The serotonin transporter-linked promoter region (5-HTTLPR) polymorphism of the serotonin transporter gene is associated with amygdala response during negative emotion. The aim of this study was to investigate whether this genotype effect on amygdala function is mediated by current serotonin transpo...

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Autores principales: Kobiella, A, Reimold, M, Ulshöfer, D E, Ikonomidou, V N, Vollmert, C, Vollstädt-Klein, S, Rietschel, M, Reischl, G, Heinz, A, Smolka, M N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309509/
https://www.ncbi.nlm.nih.gov/pubmed/22832611
http://dx.doi.org/10.1038/tp.2011.29
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author Kobiella, A
Reimold, M
Ulshöfer, D E
Ikonomidou, V N
Vollmert, C
Vollstädt-Klein, S
Rietschel, M
Reischl, G
Heinz, A
Smolka, M N
author_facet Kobiella, A
Reimold, M
Ulshöfer, D E
Ikonomidou, V N
Vollmert, C
Vollstädt-Klein, S
Rietschel, M
Reischl, G
Heinz, A
Smolka, M N
author_sort Kobiella, A
collection PubMed
description The serotonin transporter-linked promoter region (5-HTTLPR) polymorphism of the serotonin transporter gene is associated with amygdala response during negative emotion. The aim of this study was to investigate whether this genotype effect on amygdala function is mediated by current serotonin transporter (5-HTT) levels or rather by genetically induced influences during neurodevelopment, shaping brain structure. A total of 54 healthy subjects underwent functional and structural magnetic resonance imaging, [(11)C]DASB positron emission tomography and 5-HTTLPR genotyping to analyze the interrelationships between amygdala activation during processing of unpleasant stimuli, 5-HTTLPR genotype, amygdala volumes and 5-HTT levels in the midbrain and in other brain regions. In line with previous research, carriers of the short allele (S) showed increased amygdala activation. Path analysis demonstrated that this genotype effect was not procured by current 5-HTT availability but by amygdala structure, with smaller amygdala volumes in the S than in the LL genotype, as well as smaller volumes being associated with increased amygdala activation. Our findings stress the role of genetic effects during neurodevelopment.
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spelling pubmed-33095092012-04-03 How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure Kobiella, A Reimold, M Ulshöfer, D E Ikonomidou, V N Vollmert, C Vollstädt-Klein, S Rietschel, M Reischl, G Heinz, A Smolka, M N Transl Psychiatry Original Article The serotonin transporter-linked promoter region (5-HTTLPR) polymorphism of the serotonin transporter gene is associated with amygdala response during negative emotion. The aim of this study was to investigate whether this genotype effect on amygdala function is mediated by current serotonin transporter (5-HTT) levels or rather by genetically induced influences during neurodevelopment, shaping brain structure. A total of 54 healthy subjects underwent functional and structural magnetic resonance imaging, [(11)C]DASB positron emission tomography and 5-HTTLPR genotyping to analyze the interrelationships between amygdala activation during processing of unpleasant stimuli, 5-HTTLPR genotype, amygdala volumes and 5-HTT levels in the midbrain and in other brain regions. In line with previous research, carriers of the short allele (S) showed increased amygdala activation. Path analysis demonstrated that this genotype effect was not procured by current 5-HTT availability but by amygdala structure, with smaller amygdala volumes in the S than in the LL genotype, as well as smaller volumes being associated with increased amygdala activation. Our findings stress the role of genetic effects during neurodevelopment. Nature Publishing Group 2011-08 2011-08-30 /pmc/articles/PMC3309509/ /pubmed/22832611 http://dx.doi.org/10.1038/tp.2011.29 Text en Copyright © 2011 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Article
Kobiella, A
Reimold, M
Ulshöfer, D E
Ikonomidou, V N
Vollmert, C
Vollstädt-Klein, S
Rietschel, M
Reischl, G
Heinz, A
Smolka, M N
How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
title How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
title_full How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
title_fullStr How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
title_full_unstemmed How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
title_short How the serotonin transporter 5-HTTLPR polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
title_sort how the serotonin transporter 5-httlpr polymorphism influences amygdala function: the roles of in vivo serotonin transporter expression and amygdala structure
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309509/
https://www.ncbi.nlm.nih.gov/pubmed/22832611
http://dx.doi.org/10.1038/tp.2011.29
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