β-Cells with Relative Low HIMP1 Overexpression Levels in a Transgenic Mouse Line Enhance Basal Insulin Production and Hypoxia/Hypoglycemia Tolerance

Rodent pancreatic β-cells that naturally lack hypoglycemia/hypoxia inducible mitochondrial protein 1 (HIMP1) are susceptible to hypoglycemia and hypoxia influences. A linkage between the hypoglycemia/hypoxia susceptibility and the lack of HIMP1 is suggested in a recent study using transformed β-cell...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoping, Degenstein, Linda, Cao, Yun, Stein, Jeffrey, Osei, Kwame, Wang, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309936/
https://www.ncbi.nlm.nih.gov/pubmed/22470529
http://dx.doi.org/10.1371/journal.pone.0034126

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309936/
https://www.ncbi.nlm.nih.gov/pubmed/22470529
http://dx.doi.org/10.1371/journal.pone.0034126

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