Degradation of Internalized αvβ5 Integrin Is Controlled by uPAR Bound uPA: Effect on β1 Integrin Activity and α-SMA Stress Fiber Assembly

Myofibroblasts (Mfs) that persist in a healing wound promote extracellular matrix (ECM) accumulation and excessive tissue contraction. Increased levels of integrin αvβ5 promote the Mf phenotype and other fibrotic markers. Previously we reported that maintaining uPA (urokinase plasminogen activator)...

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Detalles Bibliográficos
Autores principales: Wang, Lingyan, Pedroja, Benjamin S., Meyers, Erin E., Garcia, Angelo L., Twining, Sally S., Bernstein, Audrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309951/
https://www.ncbi.nlm.nih.gov/pubmed/22470492
http://dx.doi.org/10.1371/journal.pone.0033915

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309951/
https://www.ncbi.nlm.nih.gov/pubmed/22470492
http://dx.doi.org/10.1371/journal.pone.0033915

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