Chronic Immune Activation in HIV-1 Infection Contributes to Reduced Interferon Alpha Production via Enhanced CD40:CD40 Ligand Interaction

Although a signature of increased interferon (IFN-)alpha production is observed in HIV-1 infection, the response of circulating plasmacytoid dendritic cells (PDC) to Toll-like receptor ligand stimulation is substantially impaired. This functional PDC deficit, which we specifically observed in HIV-1...

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Detalles Bibliográficos
Autores principales: Donhauser, Norbert, Pritschet, Kathrin, Helm, Martin, Harrer, Thomas, Schuster, Philipp, Ries, Moritz, Bischof, Georg, Vollmer, Jörg, Smola, Sigrun, Schmidt, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309969/
https://www.ncbi.nlm.nih.gov/pubmed/22470494
http://dx.doi.org/10.1371/journal.pone.0033925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309969/
https://www.ncbi.nlm.nih.gov/pubmed/22470494
http://dx.doi.org/10.1371/journal.pone.0033925

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