Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

BACKGROUND: The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore, secretory pathway dysfunction can be highly detrimenta...

Descripción completa

Detalles Bibliográficos
Autores principales: Tyo, Keith EJ, Liu, Zihe, Petranovic, Dina, Nielsen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310788/
https://www.ncbi.nlm.nih.gov/pubmed/22380681
http://dx.doi.org/10.1186/1741-7007-10-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310788/
https://www.ncbi.nlm.nih.gov/pubmed/22380681
http://dx.doi.org/10.1186/1741-7007-10-16

Ejemplares similares