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Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress
BACKGROUND: The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore, secretory pathway dysfunction can be highly detrimenta...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310788/ https://www.ncbi.nlm.nih.gov/pubmed/22380681 http://dx.doi.org/10.1186/1741-7007-10-16 |