Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis

Expansion of (CTG)(n)•(CAG)(n )trinucleotide repeat (TNR) microsatellite sequences is the cause of more than a dozen human neurodegenerative diseases. (CTG)(n )and (CAG)(n )repeats form imperfectly base paired hairpins that tend to expand in vivo in a length-dependent manner. Yeast, mouse and human...

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Detalles Bibliográficos
Autores principales: Liu, Guoqi, Leffak, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310812/
https://www.ncbi.nlm.nih.gov/pubmed/22369689
http://dx.doi.org/10.1186/2045-3701-2-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310812/
https://www.ncbi.nlm.nih.gov/pubmed/22369689
http://dx.doi.org/10.1186/2045-3701-2-7

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