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Instability of (CTG)(n)•(CAG)(n )trinucleotide repeats and DNA synthesis
Expansion of (CTG)(n)•(CAG)(n )trinucleotide repeat (TNR) microsatellite sequences is the cause of more than a dozen human neurodegenerative diseases. (CTG)(n )and (CAG)(n )repeats form imperfectly base paired hairpins that tend to expand in vivo in a length-dependent manner. Yeast, mouse and human...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310812/ https://www.ncbi.nlm.nih.gov/pubmed/22369689 http://dx.doi.org/10.1186/2045-3701-2-7 |