The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

Radiotherapy is a treatment choice for local control of breast cancer. However, intrinsic radioresistance of cancer cells limits therapeutic efficacy. We have recently validated that SCF (SKP1, Cullins, and F-box protein) E3 ubiquitin ligase is an attractive radiosensitizing target. Here we tested o...

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Detalles Bibliográficos
Autores principales: Yang, Dong, Tan, Mingjia, Wang, Gongxian, Sun, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310880/
https://www.ncbi.nlm.nih.gov/pubmed/22457814
http://dx.doi.org/10.1371/journal.pone.0034079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310880/
https://www.ncbi.nlm.nih.gov/pubmed/22457814
http://dx.doi.org/10.1371/journal.pone.0034079

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