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The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating Enzyme

Radiotherapy is a treatment choice for local control of breast cancer. However, intrinsic radioresistance of cancer cells limits therapeutic efficacy. We have recently validated that SCF (SKP1, Cullins, and F-box protein) E3 ubiquitin ligase is an attractive radiosensitizing target. Here we tested o...

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Detalles Bibliográficos
Autores principales:	Yang, Dong, Tan, Mingjia, Wang, Gongxian, Sun, Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310880/ https://www.ncbi.nlm.nih.gov/pubmed/22457814 http://dx.doi.org/10.1371/journal.pone.0034079

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