SCD1 Inhibition Causes Cancer Cell Death by Depleting Mono-Unsaturated Fatty Acids

Increased metabolism is a requirement for tumor cell proliferation. To understand the dependence of tumor cells on fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN,...

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Detalles Bibliográficos
Autores principales: Mason, Paul, Liang, Beirong, Li, Lingyun, Fremgen, Trisha, Murphy, Erin, Quinn, Angela, Madden, Stephen L., Biemann, Hans-Peter, Wang, Bing, Cohen, Aharon, Komarnitsky, Svetlana, Jancsics, Kate, Hirth, Brad, Cooper, Christopher G. F., Lee, Edward, Wilson, Sean, Krumbholz, Roy, Schmid, Steven, Xiang, Yibin, Booker, Michael, Lillie, James, Carter, Kara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310881/
https://www.ncbi.nlm.nih.gov/pubmed/22457791
http://dx.doi.org/10.1371/journal.pone.0033823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310881/
https://www.ncbi.nlm.nih.gov/pubmed/22457791
http://dx.doi.org/10.1371/journal.pone.0033823

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