Src Inhibitors, PP2 and Dasatinib, Increase Retinoic Acid-Induced Association of Lyn and c-Raf (S259) and Enhance MAPK Dependent Differentiation of Myeloid Leukemia Cells

All-trans-retinoic-acid (ATRA)-induced differentiation of human myeloid leukemia cells is characterized by persistent MAPK signaling. Fragmentary data suggests Src family kinase (SFK) inhibitors enhance differentiation and thus have potential therapeutic value. The present study shows that SFK inhib...

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Detalles Bibliográficos
Autores principales: Congleton, Johanna, MacDonald, Robert, Yen, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310950/
https://www.ncbi.nlm.nih.gov/pubmed/22182854
http://dx.doi.org/10.1038/leu.2011.390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310950/
https://www.ncbi.nlm.nih.gov/pubmed/22182854
http://dx.doi.org/10.1038/leu.2011.390

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