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MGMT promoter methylation in gliomas-assessment by pyrosequencing and quantitative methylation-specific PCR
BACKGROUND: Methylation of the O(6)-methylguanine-DNA methyltransferase (MGMT) gene promoter is a favorable prognostic factor in glioblastoma patients. However, reported methylation frequencies vary significantly partly due to lack of consensus in the choice of analytical method. METHOD: We examined...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311573/ https://www.ncbi.nlm.nih.gov/pubmed/22390413 http://dx.doi.org/10.1186/1479-5876-10-36 |