Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels

OBJECTIVE: Pigment epithelium-derived factor (PEDF) belongs to the serpin family of peptidase inhibitors (serpin F1) and is among the most abundant glycoproteins secreted by adipocytes. In vitro and mouse in vivo data revealed PEDF as a candidate mediator of obesity-induced insulin resistance. There...

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Detalles Bibliográficos
Autores principales: Böhm, Anja, Ordelheide, Anna-Maria, Machann, Jürgen, Heni, Martin, Ketterer, Caroline, Machicao, Fausto, Schick, Fritz, Stefan, Norbert, Fritsche, Andreas, Häring, Hans-Ulrich, Staiger, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311576/
https://www.ncbi.nlm.nih.gov/pubmed/22457810
http://dx.doi.org/10.1371/journal.pone.0034035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311576/
https://www.ncbi.nlm.nih.gov/pubmed/22457810
http://dx.doi.org/10.1371/journal.pone.0034035

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