Hypoxia Negatively Regulates Antimetastatic PEDF in Melanoma Cells by a Hypoxia Inducible Factor-Independent, Autophagy Dependent Mechanism

Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor (SERPIN) superfamily, displays a potent antiangiogenic and antimetastatic activity in a broad range of tumor types. Melanocytes and low aggressive melanoma cells secrete high levels of PEDF, while its expression is l...

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Detalles Bibliográficos
Autores principales: Fernández-Barral, Asunción, Orgaz, José Luis, Gomez, Valentí, del Peso, Luis, Calzada, María José, Jiménez, Benilde
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311626/
https://www.ncbi.nlm.nih.gov/pubmed/22457728
http://dx.doi.org/10.1371/journal.pone.0032989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311626/
https://www.ncbi.nlm.nih.gov/pubmed/22457728
http://dx.doi.org/10.1371/journal.pone.0032989

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