Rational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors

The tremendous social and economic impact of thrombotic disorders, together with the considerable risks associated to the currently available therapies, prompt for the development of more efficient and safer anticoagulants. Novel peptide-based thrombin inhibitors were identified using in silico stru...

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Detalles Bibliográficos
Autores principales: Figueiredo, Ana C., Clement, Cristina C., Zakia, Sheuli, Gingold, Julian, Philipp, Manfred, Pereira, Pedro J. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311629/
https://www.ncbi.nlm.nih.gov/pubmed/22457833
http://dx.doi.org/10.1371/journal.pone.0034354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311629/
https://www.ncbi.nlm.nih.gov/pubmed/22457833
http://dx.doi.org/10.1371/journal.pone.0034354

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