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Purkinje Cell-Specific Ablation of Ca(V)2.1 Channels is Sufficient to Cause Cerebellar Ataxia in Mice
The Cacna1a gene encodes the α(1A) subunit of voltage-gated Ca(V)2.1 Ca(2+) channels that are involved in neurotransmission at central synapses. Ca(V)2.1-α(1)-knockout (α1KO) mice, which lack Ca(V)2.1 channels in all neurons, have a very severe phenotype of cerebellar ataxia and dystonia, and usuall...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311848/ https://www.ncbi.nlm.nih.gov/pubmed/21870131 http://dx.doi.org/10.1007/s12311-011-0302-1 |