Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney—potential mechanism of lifespan extension

Mice homozygous for the targeted disruption of the growth hormone (GH) receptor (Ghr) gene (GH receptor knockout; GHRKO; KO) are hypoinsulinemic, highly insulin sensitive, normoglycemic, and long-lived. Visceral fat removal (VFR) is a surgical intervention which improves insulin signaling in normal...

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Detalles Bibliográficos
Autores principales: Gesing, Adam, Masternak, Michal M., Wang, Feiya, Karbownik-Lewinska, Malgorzata, Bartke, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312636/
https://www.ncbi.nlm.nih.gov/pubmed/21431351
http://dx.doi.org/10.1007/s11357-011-9232-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312636/
https://www.ncbi.nlm.nih.gov/pubmed/21431351
http://dx.doi.org/10.1007/s11357-011-9232-6

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