Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice

Constitutive macroautophagy involved in the turnover of defective long-lived proteins and organelles is crucial for neuronal homeostasis. We hypothesized that macroautophagic dysregulation in selective brain regions was associated with memory impairment in aged mice. We used the single-trial object...

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Detalles Bibliográficos
Autores principales: Soontornniyomkij, Virawudh, Risbrough, Victoria B., Young, Jared W., Soontornniyomkij, Benchawanna, Jeste, Dilip V., Achim, Cristian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312638/
https://www.ncbi.nlm.nih.gov/pubmed/21431350
http://dx.doi.org/10.1007/s11357-011-9234-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312638/
https://www.ncbi.nlm.nih.gov/pubmed/21431350
http://dx.doi.org/10.1007/s11357-011-9234-4

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