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Increased hippocampal accumulation of autophagosomes predicts short-term recognition memory impairment in aged mice
Constitutive macroautophagy involved in the turnover of defective long-lived proteins and organelles is crucial for neuronal homeostasis. We hypothesized that macroautophagic dysregulation in selective brain regions was associated with memory impairment in aged mice. We used the single-trial object...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312638/ https://www.ncbi.nlm.nih.gov/pubmed/21431350 http://dx.doi.org/10.1007/s11357-011-9234-4 |