Advances in using PARP inhibitors to treat cancer

The poly (ADP-ribose) polymerase (PARP) family of enzymes plays a critical role in the maintenance of DNA integrity as part of the base excision pathway of DNA repair. PARP1 is overexpressed in a variety of cancers, and its expression has been associated with overall prognosis in cancer, especially...

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Detalles Bibliográficos
Autores principales: Kummar, Shivaani, Chen, Alice, Parchment, Ralph E, Kinders, Robert J, Ji, Jay, Tomaszewski, Joseph E, Doroshow, James H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312820/
https://www.ncbi.nlm.nih.gov/pubmed/22401667
http://dx.doi.org/10.1186/1741-7015-10-25

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312820/
https://www.ncbi.nlm.nih.gov/pubmed/22401667
http://dx.doi.org/10.1186/1741-7015-10-25

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