Monoclonal Antibodies to Meningococcal Factor H Binding Protein with Overlapping Epitopes and Discordant Functional Activity

BACKGROUND: Meningococcal factor H binding protein (fHbp) is a promising vaccine candidate. Anti-fHbp antibodies can bind to meningococci and elicit complement-mediated bactericidal activity directly. The antibodies also can block binding of the human complement down-regulator, factor H (fH). Withou...

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Detalles Bibliográficos
Autores principales: Giuntini, Serena, Beernink, Peter T., Reason, Donald C., Granoff, Dan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312907/
https://www.ncbi.nlm.nih.gov/pubmed/22461909
http://dx.doi.org/10.1371/journal.pone.0034272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312907/
https://www.ncbi.nlm.nih.gov/pubmed/22461909
http://dx.doi.org/10.1371/journal.pone.0034272

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