Impaired Cleavage of Preproinsulin Signal Peptide Linked to Autosomal-Dominant Diabetes

Recently, missense mutations upstream of preproinsulin’s signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling and assays of proinsulin export and insulin and C-pe...

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Detalles Bibliográficos
Autores principales: Liu, Ming, Lara-Lemus, Roberto, Shan, Shu-ou, Wright, Jordan, Haataja, Leena, Barbetti, Fabrizio, Guo, Huan, Larkin, Dennis, Arvan, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Islet Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314357/
https://www.ncbi.nlm.nih.gov/pubmed/22357960
http://dx.doi.org/10.2337/db11-0878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314357/
https://www.ncbi.nlm.nih.gov/pubmed/22357960
http://dx.doi.org/10.2337/db11-0878

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