Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action

BACKGROUND: A better anti-malarial efficiency and lower neurotoxicity have been reported for mefloquine (MQ) (+)- enantiomer. However, the importance of stereoselectivity remains poorly understood as the anti-malarial activity of pure enantiomer MQ analogues has never been described. Building on the...

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Detalles Bibliográficos
Autores principales: Mullié, Catherine, Jonet, Alexia, Desgrouas, Camille, Taudon, Nicolas, Sonnet, Pascal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314553/
https://www.ncbi.nlm.nih.gov/pubmed/22401346
http://dx.doi.org/10.1186/1475-2875-11-65

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314553/
https://www.ncbi.nlm.nih.gov/pubmed/22401346
http://dx.doi.org/10.1186/1475-2875-11-65

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