Cargando…

Differences in anti-malarial activity of 4-aminoalcohol quinoline enantiomers and investigation of the presumed underlying mechanism of action

BACKGROUND: A better anti-malarial efficiency and lower neurotoxicity have been reported for mefloquine (MQ) (+)- enantiomer. However, the importance of stereoselectivity remains poorly understood as the anti-malarial activity of pure enantiomer MQ analogues has never been described. Building on the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mullié, Catherine, Jonet, Alexia, Desgrouas, Camille, Taudon, Nicolas, Sonnet, Pascal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314553/ https://www.ncbi.nlm.nih.gov/pubmed/22401346 http://dx.doi.org/10.1186/1475-2875-11-65

Ejemplares similares

Enantiomerically pure amino-alcohol quinolines: in vitro anti-malarial activity in combination with dihydroartemisinin, cytotoxicity and in vivo efficacy in a Plasmodium berghei mouse model
por: Mullié, Catherine, et al.
Publicado: (2014)

In vitro and in vivo combination of cepharanthine with anti-malarial drugs
por: Desgrouas, Camille, et al.
Publicado: (2014)

Study of Iron Piperazine-Based Chelators as Potential Siderophore Mimetics
por: Loupias, Pauline, et al.
Publicado: (2019)

Quantitative Analysis of Cepharanthine in Plasma Based on Semiautomatic Microextraction by Packed Sorbent Combined with Liquid Chromatography
por: Desgrouas, Camille, et al.
Publicado: (2014)

Mefloquine—An Aminoalcohol with Promising Antischistosomal Properties in Mice
por: Keiser, Jennifer, et al.
Publicado: (2009)

Synthesis and Antileishmanial Activity of Lipophilic Aromatic Aminoalcohols
por: Reis Corrales, Roberta Novaes, et al.
Publicado: (2010)

Aspirination of α-Aminoalcohol (Sarpogrelate M1)
por: Park, Sunhwa, et al.
Publicado: (2016)

Trypanocidal Activity of Long Chain Diamines and Aminoalcohols
por: Legarda-Ceballos, Ana L., et al.
Publicado: (2015)

The Influence of Aminoalcohols on ZnO Films’ Structure
por: Nowak, Ewelina, et al.
Publicado: (2022)

In vitro antiplasmodial activity of cepharanthine
por: Desgrouas, Camille, et al.
Publicado: (2014)

Synthesis and Biological Application of Isosteviol-Based 1,3-Aminoalcohols
por: Ozsvár, Dániel, et al.
Publicado: (2021)

Aminoalcohol-Induced Activation of Organophosphorus Hydrolase (OPH) towards Diisopropylfluorophosphate (DFP)
por: Li, Dandan, et al.
Publicado: (2017)

Synthesis and Application of 1,2-Aminoalcohols with Neoisopulegol-Based Octahydrobenzofuran Core
por: Bamou, Fatima Zahra, et al.
Publicado: (2019)

Novel carbazole aminoalcohols as inhibitors of β-hematin formation: Antiplasmodial and antischistosomal activities
por: Wang, Weisi, et al.
Publicado: (2017)

Influence of the Nature of Aminoalcohol on ZnO Films Formed by Sol-Gel Methods
por: Vilà, Anna, et al.
Publicado: (2023)

Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols
por: Milner, Erin, et al.
Publicado: (2010)

Synthesis and Evaluation of Chalcone-Quinoline Based Molecular Hybrids as Potential Anti-Malarial Agents
por: Vinindwa, Bonani, et al.
Publicado: (2021)

Chirality of the biomolecules enhanced its stereospecific action of dihydromyricetin enantiomers
por: Umair, Muhammad, et al.
Publicado: (2020)

An Efficient, Practical, and Enantioselective Method for Synthesis of Homoallenylamides Catalyzed by an Aminoalcohol-Derived, Boron-Based Catalyst
por: Wu, Hao, et al.
Publicado: (2014)

Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction
por: Caputo, Samantha, et al.
Publicado: (2016)

Synergetic iridium and amine catalysis enables asymmetric [4+2] cycloadditions of vinyl aminoalcohols with carbonyls
por: Zhang, Mao-Mao, et al.
Publicado: (2019)

Synthesis of 1,2-Aminoalcohols through Enantioselective Aminoallylation of Ketones by Cu-Catalyzed Reductive Coupling
por: Klake, Raphael K., et al.
Publicado: (2021)

Benzimidazole and aminoalcohol derivatives show in vitro anthelmintic activity against Trichuris muris and Heligmosomoides polygyrus
por: Valderas-García, Elora, et al.
Publicado: (2022)

Palladium-Catalyzed Selective Amino- and Alkoxycarbonylation of Iodoarenes with Aliphatic Aminoalcohols as Heterobifunctional O,N-Nucleophiles
por: Kollár, László, et al.
Publicado: (2023)

Metal-chloroquine derivatives as possible anti-malarial drugs: evaluation of anti-malarial activity and mode of action
por: Navarro, Maribel, et al.
Publicado: (2014)

Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids
por: Lombard, Marli C, et al.
Publicado: (2013)

Limitations of Trifluoromethylbenzoimidazolylbenzoic Acid as a Chiral Derivatizing Agent to Assign Absolute Configuration for β-Chiral Aminoalcohols
por: Kriegelstein, Michal, et al.
Publicado: (2022)

Synthesis and Study of New Quinolineaminoethanols as Anti-Bacterial Drugs
por: Laumaillé, Pierre, et al.
Publicado: (2019)

N-methyl-2-pyridone-5-carboxamide (2PY)—Major Metabolite of Nicotinamide: An Update on an Old Uremic Toxin
por: Lenglet, Aurélie, et al.
Publicado: (2016)

Cytotoxicity of enantiomers of gossypol.
por: Joseph, A. E., et al.
Publicado: (1986)

Synergistic anti-malarial action of cryptolepine and artemisinins
por: Forkuo, Arnold D., et al.
Publicado: (2016)

What is presumed when we presume consent?
por: Pierscionek, Barbara K
Publicado: (2008)

The cytotoxicity study of praziquantel enantiomers
por: Sun, Qian, et al.
Publicado: (2016)

Synthesis of both enantiomers of halitunal
por: Shimano, Kazunori, et al.
Publicado: (1996)

Copper (II) Ions Induced Self-Disproportionation of Enantiomers in Capillary Electrophoresis for the Quantification of Atenolol Enantiomers
por: Hu, Shaoqiang
Publicado: (2023)

Purifying and Characterizing Bacterially Expressed Soluble Lactate Dehydrogenase from Plasmodium knowlesi for the Development of Anti-Malarial Drugs
por: Salim, Nurhainis Ogu, et al.
Publicado: (2021)

Análisis estructural, por R. M. N. de 13c, de algunos derivados de aminoalcoholes opticamente activos
por: Huerta Moreno, María Guadalupe
Publicado: (1987)

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs
por: Havránková, Eva, et al.
Publicado: (2020)

A New Dioxazolone for the Synthesis of 1,2‐Aminoalcohols via Iridium(III)‐Catalyzed C(sp(3))−H Amidation
por: Antien, Kevin, et al.
Publicado: (2021)

Chiral Aminoalcohol-Derived δ-Lactams Provide Easy Access to Piperidines and Acyclic Five-Carbon Building Blocks Bearing a Tertiary and a Quaternary Stereocenter
por: Llor, Núria, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v904873tnupa9pqik88c57usmh