Fusion of the Mycobacterium tuberculosis Antigen 85A to an Oligomerization Domain Enhances Its Immunogenicity in Both Mice and Non-Human Primates

To prevent important infectious diseases such as tuberculosis, malaria and HIV, vaccines inducing greater T cell responses are required. In this study, we investigated whether fusion of the M. tuberculosis antigen 85A to recently described adjuvant IMX313, a hybrid avian C4bp oligomerization domain,...

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Detalles Bibliográficos
Autores principales: Spencer, Alexandra J., Hill, Fergal, Honeycutt, Jared D., Cottingham, Matthew G., Bregu, Migena, Rollier, Christine S., Furze, Julie, Draper, Simon J., Søgaard, Karen C., Gilbert, Sarah C., Wyllie, David H., Hill, Adrian V. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314664/
https://www.ncbi.nlm.nih.gov/pubmed/22470455
http://dx.doi.org/10.1371/journal.pone.0033555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314664/
https://www.ncbi.nlm.nih.gov/pubmed/22470455
http://dx.doi.org/10.1371/journal.pone.0033555

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