Cargando…

Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling in Interstitial Macrophages and Myofibroblasts

Interstitial fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). Emerging data indicate that rapamycin can ameliorate kidney fibrosis by reducing the interstitial infiltrates and accumulation of extra cellular matrix (ECM). However, the cellular mechanism that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Guochun, Chen, Huihui, Wang, Chang, Peng, Youming, Sun, Lin, Liu, Hong, Liu, Fuyou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314672/ https://www.ncbi.nlm.nih.gov/pubmed/22470459 http://dx.doi.org/10.1371/journal.pone.0033626

Ejemplares similares

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis
por: Lawrence, Jessica, et al.
Publicado: (2018)

Blockade of the mTOR signaling pathway with rapamycin ameliorates aristolochic acid nephropathy
por: Wu, Minmin, et al.
Publicado: (2020)

Rapamycin Exacerbates Staphylococcus aureus Pneumonia by Inhibiting mTOR-RPS6 in Macrophages
por: Yu, Fang-Yi, et al.
Publicado: (2023)

Mechanistic Target of Rapamycin (mTOR) in the Cancer Setting
por: Murray, James T., et al.
Publicado: (2018)

Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor
por: Artoni, Filippo, et al.
Publicado: (2023)

Effects of the mTOR inhibitor Rapamycin on Monocyte-Secreted Chemokines
por: Lin, Hugo You-Hsien, et al.
Publicado: (2014)

Advances in the mTOR signaling pathway and its inhibitor rapamycin in epilepsy
por: Zhao, Wei, et al.
Publicado: (2023)

Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer
por: Cao, Guo-dong, et al.
Publicado: (2016)

The Role of Mammalian Target of Rapamycin (mTOR) in Insulin Signaling
por: Yoon, Mee-Sup
Publicado: (2017)

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration
por: Querfurth, Henry, et al.
Publicado: (2021)

GOLPH3 modulates mTOR signaling and rapamycin sensitivity in cancer
por: Scott, Kenneth L., et al.
Publicado: (2009)

Rapamycin Attenuates High Glucose-Induced Inflammation Through Modulation of mTOR/NF-κB Pathways in Macrophages
por: Dai, Jiezhi, et al.
Publicado: (2019)

Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
por: Seto, Belinda
Publicado: (2012)

mTOR kinase structure, mechanism and regulation by the rapamycin-binding domain
por: Yang, Haijuan, et al.
Publicado: (2013)

Brain size is controlled by the mammalian target of rapamycin (mTOR) in mice
por: Kim, Woo-Yang
Publicado: (2015)

The Mechanistic Target of Rapamycin (mTOR): Novel Considerations as an Antiviral Treatment
por: Maiese, Kenneth
Publicado: (2020)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
por: Spormann, Luise, et al.
Publicado: (2020)

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR
por: Zhang, Xiaoli, et al.
Publicado: (2019)

1,25-(OH)(2)D(3) ameliorates renal interstitial fibrosis in UUO rats through the AMPKα/mTOR pathway
por: Tian, Shasha, et al.
Publicado: (2021)

mTOR regulates neuroprotective effect of immunized CD4+Foxp3+ T cells in optic nerve ischemia
por: Chen, Guochun, et al.
Publicado: (2016)

The mTOR inhibitor Rapamycin protects from premature cellular senescence early after experimental kidney transplantation
por: Hoff, Uwe, et al.
Publicado: (2022)

Regulation of Gene Expression in Hepatic Cells by the Mammalian Target of Rapamycin (mTOR)
por: Jimenez, Rosa H., et al.
Publicado: (2010)

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
por: García-Martínez, Juan M., et al.
Publicado: (2009)

The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice
por: Hartman, Adam L., et al.
Publicado: (2012)

The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses
por: Soliman, Ghada A.
Publicado: (2013)

mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration
por: Norwitz, Nicholas G., et al.
Publicado: (2020)

Mannan-binding lectin ameliorates renal fibrosis by suppressing macrophage-to-myofibroblast transition
por: Xu, Li, et al.
Publicado: (2023)

Temporal changes in mammalian target of rapamycin (mTOR) and phosphorylated-mTOR expressions in the hippocampal CA1 region of rat with vascular dementia
por: Park, Jin-A, et al.
Publicado: (2017)

Rapamycin-Resistant mTOR Activity Is Required for Sensory Axon Regeneration Induced by a Conditioning Lesion
por: Chen, Weitao, et al.
Publicado: (2017)

Coenzyme Q10 Ameliorates Pancreatic Fibrosis via the ROS-Triggered mTOR Signaling Pathway
por: Xue, Ran, et al.
Publicado: (2019)

TGF-β promotes pericyte-myofibroblast transition in subretinal fibrosis through the Smad2/3 and Akt/mTOR pathways
por: Zhao, Zhenzhen, et al.
Publicado: (2022)

Aldosterone promotes renal interstitial fibrosis via the AIF-1/AKT/mTOR signaling pathway
por: Yuan, Xueying, et al.
Publicado: (2019)

Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes
por: Wang, Guo Yan, et al.
Publicado: (2023)

Rapamycin regulates the balance between cardiomyocyte apoptosis and autophagy in chronic heart failure by inhibiting mTOR signaling
por: Gao, Guangyuan, et al.
Publicado: (2020)

Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer
por: Chan, S
Publicado: (2004)

New targets for therapy in breast cancer: Mammalian target of rapamycin (mTOR) antagonists
por: Carraway, Hetty, et al.
Publicado: (2004)

Longitudinal Imaging Studies of Tumor Microenvironment in Mice Treated with the mTOR Inhibitor Rapamycin
por: Saito, Keita, et al.
Publicado: (2012)

Activation of mammalian target of rapamycin (mTOR) in triple negative feline mammary carcinomas
por: Maniscalco, Lorella, et al.
Publicado: (2013)

ETV7 is an essential component of a rapamycin-insensitive mTOR complex in cancer
por: Harwood, Franklin C., et al.
Publicado: (2018)

Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma
por: Caro-Vegas, Carolina, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hekp5k87pl5uu7ouif5hd2sgcf