Fumarate Is Cardioprotective via Activation of the Nrf2 Antioxidant Pathway

The citric acid cycle (CAC) metabolite fumarate has been proposed to be cardioprotective; however, its mechanisms of action remain to be determined. To augment cardiac fumarate levels and to assess fumarate's cardioprotective properties, we generated fumarate hydratase (Fh1) cardiac knockout (K...

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Detalles Bibliográficos
Autores principales: Ashrafian, Houman, Czibik, Gabor, Bellahcene, Mohamed, Aksentijević, Dunja, Smith, Anthony C., Mitchell, Sarah J., Dodd, Michael S., Kirwan, Jennifer, Byrne, Jonathan J., Ludwig, Christian, Isackson, Henrik, Yavari, Arash, Støttrup, Nicolaj B., Contractor, Hussain, Cahill, Thomas J., Sahgal, Natasha, Ball, Daniel R., Birkler, Rune I.D., Hargreaves, Iain, Tennant, Daniel A., Land, John, Lygate, Craig A., Johannsen, Mogens, Kharbanda, Rajesh K., Neubauer, Stefan, Redwood, Charles, de Cabo, Rafael, Ahmet, Ismayil, Talan, Mark, Günther, Ulrich L., Robinson, Alan J., Viant, Mark R., Pollard, Patrick J., Tyler, Damian J., Watkins, Hugh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314920/
https://www.ncbi.nlm.nih.gov/pubmed/22405071
http://dx.doi.org/10.1016/j.cmet.2012.01.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314920/
https://www.ncbi.nlm.nih.gov/pubmed/22405071
http://dx.doi.org/10.1016/j.cmet.2012.01.017

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