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A Bayesian View on Cryo-EM Structure Determination

Three-dimensional (3D) structure determination by single-particle analysis of cryo-electron microscopy (cryo-EM) images requires many parameters to be determined from extremely noisy data. This makes the method prone to overfitting, that is, when structures describe noise rather than signal, in part...

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Detalles Bibliográficos
Autor principal:	Scheres, Sjors H.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314964/ https://www.ncbi.nlm.nih.gov/pubmed/22100448 http://dx.doi.org/10.1016/j.jmb.2011.11.010

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