Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice

The Bcl-2 regulated apoptosis pathway is critical for the elimination of autoreactive lymphocytes, thereby precluding autoimmunity. T cells escaping this process can be kept in check by regulatory T (Treg) cells expressing the transcription and lineage commitment factor Foxp3. Despite the well-estab...

Descripción completa

Detalles Bibliográficos
Autores principales: Tischner, Denise, Gaggl, Irene, Peschel, Ines, Kaufmann, Manuel, Tuzlak, Selma, Drach, Mathias, Thuille, Nikolaus, Villunger, Andreas, Jan Wiegers, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314992/
https://www.ncbi.nlm.nih.gov/pubmed/22257939
http://dx.doi.org/10.1016/j.jaut.2011.12.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314992/
https://www.ncbi.nlm.nih.gov/pubmed/22257939
http://dx.doi.org/10.1016/j.jaut.2011.12.008

Ejemplares similares