Inhibitors of human histone deacetylase with potent activity against the African trypanosome Trypanosoma brucei

A number of hydroxamic acid derivatives which inhibit human histone deacetylases were investigated for efficacy against cultured bloodstream form Trypanosoma brucei. Three out of the four classes tested displayed significant activity. The majority of compounds blocked parasite growth in the submicro...

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Detalles Bibliográficos
Autores principales: Kelly, John M., Taylor, Martin C., Horn, David, Loza, Einars, Kalvinsh, Ivars, Björkling, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314994/
https://www.ncbi.nlm.nih.gov/pubmed/22326398
http://dx.doi.org/10.1016/j.bmcl.2012.01.072

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314994/
https://www.ncbi.nlm.nih.gov/pubmed/22326398
http://dx.doi.org/10.1016/j.bmcl.2012.01.072

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