Kinase Activity of Fission Yeast Mph1 Is Required for Mad2 and Mad3 to Stably Bind the Anaphase Promoting Complex

Defects in chromosome segregation result in aneuploidy, which can lead to disease or cell death [1, 2]. The spindle checkpoint delays anaphase onset until all chromosomes are attached to spindle microtubules in a bipolar fashion [3, 4]. Mad2 is a key checkpoint component that undergoes conformationa...

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Detalles Bibliográficos
Autores principales: Zich, Judith, Sochaj, Alicja M., Syred, Heather M., Milne, Laura, Cook, Atlanta G., Ohkura, Hiro, Rappsilber, Juri, Hardwick, Kevin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315010/
https://www.ncbi.nlm.nih.gov/pubmed/22281223
http://dx.doi.org/10.1016/j.cub.2011.12.049

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315010/
https://www.ncbi.nlm.nih.gov/pubmed/22281223
http://dx.doi.org/10.1016/j.cub.2011.12.049

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