Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations

The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying synergistic activation remains mysterious. In particul...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Yuanyuan, Yang, Fan, Cao, Xu, Yarov-Yarovoy, Vladimir, Wang, KeWei, Zheng, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315147/
https://www.ncbi.nlm.nih.gov/pubmed/22412190
http://dx.doi.org/10.1085/jgp.201110724

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315147/
https://www.ncbi.nlm.nih.gov/pubmed/22412190
http://dx.doi.org/10.1085/jgp.201110724

Ejemplares similares